Drug interactions
Mitoxantrone + Palifermin
Severity: Major
Mitoxantrone and Palifermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic chemotherapy stimulates epithelial cell proliferation and has been associated with worse and longer-lasting oral mucositis. Mitoxantrone is a cytotoxic agent that damages rapidly dividing mucosal cells.
What this interaction means in plain words
Mitoxantrone and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitoxantrone belongs to Central Nervous System; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-driven proliferation of epithelial cells increases their sensitivity to cytotoxic chemotherapy.
What to do
Do not give palifermin within 24 hours before, during, or after mitoxantrone. Separate dosing by more than 24 hours on either side.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitoxantrone
Other interactions of Palifermin
Frequently asked questions
Can I take Mitoxantrone with Palifermin?
MediHelp rates the interaction as major. Mitoxantrone and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin given close to cytotoxic chemotherapy stimulates epithelial cell proliferation and has been associated with worse and longer-lasting oral mucositis. Mitoxantrone is a cytotoxic agent that damages rapidly dividing mucosal cells.
How serious is the interaction between Mitoxantrone and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or after mitoxantrone. Separate dosing by more than 24 hours on either side.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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