Drug interactions
Mitoxantrone + Safinamide
Severity: Moderate
Mitoxantrone and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitoxantrone is a BCRP substrate and safinamide can inhibit BCRP. This may raise mitoxantrone exposure and increase myelosuppression or cardiotoxicity. Intravenous administration limits the intestinal effect, so the impact is probably small.
What this interaction means in plain words
Mitoxantrone and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Safinamide inhibits BCRP, potentially reducing efflux and clearance of mitoxantrone.
What to do
Monitor blood counts and cardiac function per standard mitoxantrone protocols. Adjust the dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Mitoxantrone
Frequently asked questions
Can I take Mitoxantrone with Safinamide?
MediHelp rates the interaction as moderate. Mitoxantrone and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitoxantrone is a BCRP substrate and safinamide can inhibit BCRP. This may raise mitoxantrone exposure and increase myelosuppression or cardiotoxicity. Intravenous administration limits the intestinal effect, so the impact is probably small.
How serious is the interaction between Mitoxantrone and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function per standard mitoxantrone protocols. Adjust the dose if toxicity appears.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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