Drug interactions
Mitoxantrone + Sofosbuvir-velpatasvir
Severity: Moderate
Mitoxantrone and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir may increase mitoxantrone exposure because mitoxantrone is a BCRP substrate. Higher levels could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Mitoxantrone and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits BCRP, which may reduce mitoxantrone efflux and clearance.
What to do
Monitor blood counts and cardiac function, including left ventricular ejection fraction as clinically indicated. Adjust the mitoxantrone dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Mitoxantrone
Frequently asked questions
Can I take Mitoxantrone with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Mitoxantrone and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir may increase mitoxantrone exposure because mitoxantrone is a BCRP substrate. Higher levels could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Mitoxantrone and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, including left ventricular ejection fraction as clinically indicated. Adjust the mitoxantrone dose if toxicity occurs.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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