Drug interactions
Mobocertinib + Sertraline
Severity: Major
Mobocertinib and Sertraline: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib causes dose-related QTc prolongation and is metabolised by CYP3A4. Sertraline adds a small QT effect and weak CYP3A4 inhibition, which may raise mobocertinib exposure and torsade de pointes risk.
What this interaction means in plain words
Mobocertinib and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with weak CYP3A4 inhibition raising mobocertinib levels.
What to do
Avoid if possible and use an antidepressant with less QT liability. If used together, monitor ECG and electrolytes closely and reduce the mobocertinib dose as per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Lustral 100mg film coated tablets - SmPC sections 4.3/4.5 (class statement: drugs which prolong the QTc interval; "The risk of QTc prolongation and/or ventricular arrhythmias (e.g. TdP) may be increased with concomitant use of other drugs which prolong the QTc interval (e.g.") — electronic medicines compendium (UK SmPC)
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Mobocertinib with Sertraline?
MediHelp rates the interaction as major. Mobocertinib and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib causes dose-related QTc prolongation and is metabolised by CYP3A4. Sertraline adds a small QT effect and weak CYP3A4 inhibition, which may raise mobocertinib exposure and torsade de pointes risk.
How serious is the interaction between Mobocertinib and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an antidepressant with less QT liability. If used together, monitor ECG and electrolytes closely and reduce the mobocertinib dose as per labeling.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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