Drug interactions
Mobocertinib + Vardenafil
Severity: Major
Mobocertinib and Vardenafil: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for QT prolongation and torsades de pointes. Vardenafil adds a small QT effect, and mobocertinib's CYP3A4 effects may also alter vardenafil exposure.
What this interaction means in plain words
Mobocertinib and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with mobocertinib also affecting CYP3A4 activity.
What to do
Avoid vardenafil if possible and use an alternative. If unavoidable, monitor ECG and electrolytes more frequently and reduce the mobocertinib dose if QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mobocertinib and Vardenafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Vardenafil Mylan 10 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: CYP3A4 inhibitor; "Co-administration of erythromycin (500 mg three times a day), a CYP3A4 inhibitor, with vardenafil (5 mg) resulted in a 4-fold increase in vardenafil AUC") — electronic medicines compendium (UK SmPC)
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Mobocertinib with Vardenafil?
MediHelp rates the interaction as major. Mobocertinib and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for QT prolongation and torsades de pointes. Vardenafil adds a small QT effect, and mobocertinib's CYP3A4 effects may also alter vardenafil exposure.
How serious is the interaction between Mobocertinib and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vardenafil if possible and use an alternative. If unavoidable, monitor ECG and electrolytes more frequently and reduce the mobocertinib dose if QTc rises.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
