Drug interactions
Mobocertinib + Verapamil
Severity: Major
Mobocertinib and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase mobocertinib exposure, and mobocertinib prolongs the QT interval and can cause torsades de pointes. The combination raises risk of serious arrhythmia.
What this interaction means in plain words
Mobocertinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Verapamil inhibits CYP3A4-mediated mobocertinib metabolism, increasing exposure and QT risk.
What to do
Avoid if possible. If unavoidable, reduce the mobocertinib dose by about half and monitor QTc and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Mobocertinib with Verapamil?
MediHelp rates the interaction as major. Mobocertinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil may increase mobocertinib exposure, and mobocertinib prolongs the QT interval and can cause torsades de pointes. The combination raises risk of serious arrhythmia.
How serious is the interaction between Mobocertinib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the mobocertinib dose by about half and monitor QTc and electrolytes closely.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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