Drug interactions
Mobocertinib + Warfarin
Severity: Moderate
Mobocertinib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a moderate CYP3A inducer and may modestly lower exposure to the R-enantiomer of warfarin, reducing the INR. The clinical effect is expected to be limited, but warfarin has a narrow therapeutic index.
What this interaction means in plain words
Mobocertinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak to moderate induction of CYP3A4 increases metabolism of R-warfarin.
What to do
Check INR more often after starting or stopping mobocertinib and adjust the warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Mobocertinib with Warfarin?
MediHelp rates the interaction as moderate. Mobocertinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mobocertinib is a moderate CYP3A inducer and may modestly lower exposure to the R-enantiomer of warfarin, reducing the INR. The clinical effect is expected to be limited, but warfarin has a narrow therapeutic index.
How serious is the interaction between Mobocertinib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often after starting or stopping mobocertinib and adjust the warfarin dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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