Drug interactions
Morphine + Nilotinib
Severity: Minor
Morphine and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2D6 in vitro, but morphine is metabolised mainly by glucuronidation, so a meaningful rise in morphine exposure is not expected. Nilotinib prolongs the QT interval, which is unrelated to morphine's effect, and the opioid may cause additional sedation.
What this interaction means in plain words
Morphine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Weak CYP2D6 inhibition, which is a minor route for morphine; no important pharmacokinetic effect established.
What to do
No dose change is generally needed; monitor analgesic response and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Morphine with Nilotinib?
MediHelp rates the interaction as minor. Morphine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP2D6 in vitro, but morphine is metabolised mainly by glucuronidation, so a meaningful rise in morphine exposure is not expected. Nilotinib prolongs the QT interval, which is unrelated to morphine's effect, and the opioid may cause additional sedation.
How serious is the interaction between Morphine and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor analgesic response and sedation.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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