Drug interactions
Morphine + Rasagiline
Severity: Moderate
Morphine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a selective MAO-B inhibitor which loses selectivity at higher doses. Opioids with MAOIs may cause additive CNS depression, hypotension or serotonin toxicity, and labeling advises caution.
What this interaction means in plain words
Morphine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may potentiate serotonergic and CNS depressant effects of morphine, not fully characterized.
What to do
Use a reduced starting dose of morphine with careful titration. Monitor for sedation, hypotension and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Morphine with Rasagiline?
MediHelp rates the interaction as moderate. Morphine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a selective MAO-B inhibitor which loses selectivity at higher doses. Opioids with MAOIs may cause additive CNS depression, hypotension or serotonin toxicity, and labeling advises caution.
How serious is the interaction between Morphine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced starting dose of morphine with careful titration. Monitor for sedation, hypotension and signs of serotonin toxicity.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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