Drug interactions
Morphine + Sotorasib
Severity: Moderate
Morphine and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib has been shown to inhibit P-glycoprotein, which may increase morphine exposure. The legacy direction of effect appears incorrect; any effect would be an increase rather than a decrease, and the clinical significance is uncertain.
What this interaction means in plain words
Morphine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Sotorasib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux, which may increase morphine absorption and CNS penetration.
What to do
Monitor for increased sedation and respiratory depression and reduce the morphine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Morphine with Sotorasib?
MediHelp rates the interaction as moderate. Morphine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib has been shown to inhibit P-glycoprotein, which may increase morphine exposure. The legacy direction of effect appears incorrect; any effect would be an increase rather than a decrease, and the clinical significance is uncertain.
How serious is the interaction between Morphine and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and respiratory depression and reduce the morphine dose if these occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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