Drug interactions
Moxisylyte + Vardenafil
Severity: Moderate
Moxisylyte and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-adrenergic blocker and vardenafil is a vasodilator, so together they can cause symptomatic hypotension. Alpha-blocker combinations with PDE5 inhibitors can produce orthostatic dizziness and syncope.
What this interaction means in plain words
Moxisylyte and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from alpha-adrenergic blockade and PDE5 inhibition.
What to do
Use the lowest vardenafil dose and ensure the patient is stable on moxisylyte before starting it. Monitor blood pressure and warn about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Moxisylyte with Vardenafil?
MediHelp rates the interaction as moderate. Moxisylyte and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-adrenergic blocker and vardenafil is a vasodilator, so together they can cause symptomatic hypotension. Alpha-blocker combinations with PDE5 inhibitors can produce orthostatic dizziness and syncope.
How serious is the interaction between Moxisylyte and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest vardenafil dose and ensure the patient is stable on moxisylyte before starting it. Monitor blood pressure and warn about orthostatic symptoms.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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