Drug interactions
Moxonidine + Oxymorphone
Severity: Moderate
Moxonidine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness and dizziness, and opioids may add to sedation and hypotension. The effect is generally modest but can matter in elderly patients.
What this interaction means in plain words
Moxonidine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and blood pressure lowering through central imidazoline/alpha-2 effects and opioid actions.
What to do
Monitor blood pressure and sedation when starting or titrating either drug. Counsel patients to rise slowly and avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Moxonidine with Oxymorphone?
MediHelp rates the interaction as moderate. Moxonidine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness and dizziness, and opioids may add to sedation and hypotension. The effect is generally modest but can matter in elderly patients.
How serious is the interaction between Moxonidine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation when starting or titrating either drug. Counsel patients to rise slowly and avoid driving if drowsy.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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