Drug interactions
Moxonidine + Ziprasidone
Severity: Moderate
Moxonidine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that causes sedation and hypotension. With ziprasidone, drowsiness and orthostatic hypotension may be additive.
What this interaction means in plain words
Moxonidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and blood pressure lowering.
What to do
Monitor blood pressure and sedation, particularly when starting therapy. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Moxonidine with Ziprasidone?
MediHelp rates the interaction as moderate. Moxonidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that causes sedation and hypotension. With ziprasidone, drowsiness and orthostatic hypotension may be additive.
How serious is the interaction between Moxonidine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, particularly when starting therapy. Counsel patients to rise slowly.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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