Drug interactions
Muromonab cd3 + Pneumococcal vaccine 13-valent
Severity: Moderate
Muromonab cd3 and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 depletes T cells and causes profound immunosuppression, which would be expected to markedly impair the antibody response to a vaccine. The conjugate vaccine is non-live and not formally contraindicated, but vaccination during treatment is unlikely to be effective.
What this interaction means in plain words
Muromonab cd3 and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
T-cell depletion through CD3 targeting impairs the T-cell-dependent response to conjugate vaccines.
What to do
Defer vaccination until immunosuppression has been reduced or finished where possible, and revaccinate or check titres afterward if given during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Muromonab cd3 and Pneumococcal vaccine 13-valent, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Muromonab cd3 with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Muromonab cd3 and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Muromonab-CD3 depletes T cells and causes profound immunosuppression, which would be expected to markedly impair the antibody response to a vaccine. The conjugate vaccine is non-live and not formally contraindicated, but vaccination during treatment is unlikely to be effective.
How serious is the interaction between Muromonab cd3 and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer vaccination until immunosuppression has been reduced or finished where possible, and revaccinate or check titres afterward if given during therapy.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
