Drug interactions
Muromonab cd3 + Ustekinumab
Severity: Major
Muromonab cd3 and Ustekinumab: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 causes profound T-cell depletion, and adding ustekinumab, an IL-12/23 inhibitor, may further weaken immune defences. This raises the risk of serious bacterial, viral and opportunistic infections.
What this interaction means in plain words
Muromonab cd3 and Ustekinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion plus IL-12/IL-23 blockade.
What to do
Avoid the combination where an alternative exists. If both are needed, monitor closely for infection and screen for latent tuberculosis before use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Muromonab cd3 with Ustekinumab?
MediHelp rates the interaction as major. Muromonab cd3 and Ustekinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Muromonab-CD3 causes profound T-cell depletion, and adding ustekinumab, an IL-12/23 inhibitor, may further weaken immune defences. This raises the risk of serious bacterial, viral and opportunistic infections.
How serious is the interaction between Muromonab cd3 and Ustekinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If both are needed, monitor closely for infection and screen for latent tuberculosis before use.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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