Drug interactions
Mycophenolate + Oxaprozin
Severity: Moderate
Mycophenolate and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin is an organic acid that may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising exposure to either drug. NSAIDs also add gastrointestinal toxicity and can impair kidney function in transplant recipients.
What this interaction means in plain words
Mycophenolate and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular anionic secretion, plus additive gastrointestinal and renal toxicity.
What to do
Monitor renal function and for gastrointestinal adverse effects or myelosuppression. Prefer avoiding NSAIDs in transplant patients where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mycophenolate and Oxaprozin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Mycophenolate with Oxaprozin?
MediHelp rates the interaction as moderate. Mycophenolate and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin is an organic acid that may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising exposure to either drug. NSAIDs also add gastrointestinal toxicity and can impair kidney function in transplant recipients.
How serious is the interaction between Mycophenolate and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for gastrointestinal adverse effects or myelosuppression. Prefer avoiding NSAIDs in transplant patients where alternatives exist.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
