Drug interactions
Mycophenolate + Pneumococcal vaccine 13-valent
Severity: Moderate
Mycophenolate and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate inhibits lymphocyte proliferation and has been associated with reduced antibody responses to pneumococcal and other inactivated vaccines in transplant recipients. The conjugate vaccine is non-live and is still recommended in these patients, although protection may be lower.
What this interaction means in plain words
Mycophenolate and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of inosine monophosphate dehydrogenase limits B- and T-lymphocyte proliferation and so reduces the antibody response.
What to do
Vaccinate as early as possible, ideally before transplantation or before starting therapy. Do not rely on a single dose in highly immunosuppressed patients; follow transplant vaccination guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Mycophenolate with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Mycophenolate and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate inhibits lymphocyte proliferation and has been associated with reduced antibody responses to pneumococcal and other inactivated vaccines in transplant recipients. The conjugate vaccine is non-live and is still recommended in these patients, although protection may be lower.
How serious is the interaction between Mycophenolate and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as early as possible, ideally before transplantation or before starting therapy. Do not rely on a single dose in highly immunosuppressed patients; follow transplant vaccination guidance.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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