Drug interactions
Mycophenolate + Probenecid
Severity: Moderate
Mycophenolate and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal tubular secretion of mycophenolic acid glucuronide, the main metabolite of mycophenolate, raising levels of both the glucuronide and the parent acid. This may increase myelosuppression and GI toxicity.
What this interaction means in plain words
Mycophenolate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid blocks renal OAT-mediated secretion of mycophenolic acid glucuronide, which can also alter enterohepatic recycling and raise mycophenolic acid exposure.
What to do
Monitor blood counts and for GI adverse effects, and consider reducing the mycophenolate dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Mycophenolate with Probenecid?
MediHelp rates the interaction as moderate. Mycophenolate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal tubular secretion of mycophenolic acid glucuronide, the main metabolite of mycophenolate, raising levels of both the glucuronide and the parent acid. This may increase myelosuppression and GI toxicity.
How serious is the interaction between Mycophenolate and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for GI adverse effects, and consider reducing the mycophenolate dose if toxicity occurs.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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