Drug interactions
Mycophenolate + Sulphasalazine
Severity: Minor
Mycophenolate and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both sulfasalazine and the mycophenolic acid glucuronide metabolite are organic anions that may compete for renal tubular secretion. This could modestly raise exposure to one or both drugs. Sulfasalazine may also reduce enterohepatic recycling effects, so the net effect is uncertain.
What this interaction means in plain words
Mycophenolate and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anion secretion; net effect not well established.
What to do
No routine adjustment is needed; monitor blood counts and clinical response when both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Frequently asked questions
Can I take Mycophenolate with Sulphasalazine?
MediHelp rates the interaction as minor. Mycophenolate and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both sulfasalazine and the mycophenolic acid glucuronide metabolite are organic anions that may compete for renal tubular secretion. This could modestly raise exposure to one or both drugs. Sulfasalazine may also reduce enterohepatic recycling effects, so the net effect is uncertain.
How serious is the interaction between Mycophenolate and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood counts and clinical response when both are used.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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