Drug interactions
Mycophenolate + Ustekinumab
Severity: Moderate
Mycophenolate and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate suppresses lymphocyte proliferation, and ustekinumab blocks IL-12/23 signalling. Together they may increase susceptibility to serious and opportunistic infections.
What this interaction means in plain words
Mycophenolate and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through different pathways.
What to do
Monitor for signs of infection and screen for latent tuberculosis before ustekinumab. Use the lowest effective immunosuppressant doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Mycophenolate with Ustekinumab?
MediHelp rates the interaction as moderate. Mycophenolate and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate suppresses lymphocyte proliferation, and ustekinumab blocks IL-12/23 signalling. Together they may increase susceptibility to serious and opportunistic infections.
How serious is the interaction between Mycophenolate and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and screen for latent tuberculosis before ustekinumab. Use the lowest effective immunosuppressant doses.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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