Drug interactions
Nadolol + Nitroglycerin rectal
Severity: Moderate
Nadolol and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers blunt the reflex tachycardia from nitroglycerin while its vasodilating and hypotensive effects remain. Together they can cause additive hypotension, dizziness or syncope, although the pair is also used intentionally in angina.
What this interaction means in plain words
Nadolol and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect of nitrate vasodilation and beta-blockade, with loss of compensatory reflex tachycardia.
What to do
Monitor blood pressure and symptoms of hypotension when starting or increasing either drug. Reduce the dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Nadolol and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers blunt the reflex tachycardia from nitroglycerin while its vasodilating and hypotensive effects remain. Together they can cause additive hypotension, dizziness or syncope, although the pair is also used intentionally in angina.
How serious is the interaction between Nadolol and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or increasing either drug. Reduce the dose if orthostatic symptoms occur.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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