Drug interactions
Nadolol + Olanzapine / samidorphan
Severity: Moderate
Nadolol and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may enhance the blood pressure lowering effect of antihypertensives such as nadolol. Patients may experience dizziness, syncope or falls, particularly at treatment initiation.
What this interaction means in plain words
Nadolol and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from olanzapine alpha-1 adrenergic antagonism combined with beta-blockade.
What to do
Monitor blood pressure and orthostatic symptoms during initiation and dose changes. Reduce the nadolol dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Nadolol and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may enhance the blood pressure lowering effect of antihypertensives such as nadolol. Patients may experience dizziness, syncope or falls, particularly at treatment initiation.
How serious is the interaction between Nadolol and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during initiation and dose changes. Reduce the nadolol dose if symptomatic hypotension occurs.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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