Drug interactions
Nadolol + Olodaterol inhaled
Severity: Major
Nadolol and Olodaterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol blocks beta-2 receptors and can antagonize the bronchodilator effect of olodaterol, and may provoke bronchospasm in patients with COPD or asthma. This reduces the benefit of the long-acting agonist.
What this interaction means in plain words
Nadolol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Avoid nonselective beta-blockers like nadolol in patients using olodaterol; if a beta-blocker is essential, choose a cardioselective one and monitor lung function and symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Olodaterol inhaled?
MediHelp rates the interaction as major. Nadolol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol blocks beta-2 receptors and can antagonize the bronchodilator effect of olodaterol, and may provoke bronchospasm in patients with COPD or asthma. This reduces the benefit of the long-acting agonist.
How serious is the interaction between Nadolol and Olodaterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers like nadolol in patients using olodaterol; if a beta-blocker is essential, choose a cardioselective one and monitor lung function and symptoms.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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