Drug interactions
Nadolol + Pentobarbital
Severity: Minor
Nadolol and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower concentrations of beta-blockers that are metabolized. Nadolol is largely excreted unchanged by the kidneys, so any reduction in its effect is expected to be small.
What this interaction means in plain words
Nadolol and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hepatic enzyme induction by pentobarbital, with limited relevance to nadolol because it is mostly renally eliminated.
What to do
No routine dose change is needed. Monitor heart rate and blood pressure if barbiturate therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Pentobarbital?
MediHelp rates the interaction as minor. Nadolol and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and can lower concentrations of beta-blockers that are metabolized. Nadolol is largely excreted unchanged by the kidneys, so any reduction in its effect is expected to be small.
How serious is the interaction between Nadolol and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor heart rate and blood pressure if barbiturate therapy is started or stopped.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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