Drug interactions
Nadolol + Phenobarbital
Severity: Minor
Nadolol and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a strong enzyme inducer that lowers levels of many beta-blockers. Nadolol is mainly eliminated unchanged by the kidneys, so the effect is expected to be minor.
What this interaction means in plain words
Nadolol and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induction of hepatic metabolism, with limited effect on the renally cleared nadolol.
What to do
Monitor heart rate and blood pressure when phenobarbital is started or stopped, and adjust nadolol only if response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Phenobarbital?
MediHelp rates the interaction as minor. Nadolol and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital is a strong enzyme inducer that lowers levels of many beta-blockers. Nadolol is mainly eliminated unchanged by the kidneys, so the effect is expected to be minor.
How serious is the interaction between Nadolol and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when phenobarbital is started or stopped, and adjust nadolol only if response changes.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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