Drug interactions
Nadolol + Phenoxybenzamine
Severity: Moderate
Nadolol and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes alpha-blockade and vasodilation, and adding nadolol can increase hypotension. In pheochromocytoma, beta-blockers are used after alpha-blockade is established to avoid unopposed alpha stimulation and hypertensive crisis.
What this interaction means in plain words
Nadolol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-adrenergic and beta-adrenergic blockade.
What to do
Start the beta-blocker only after adequate alpha-blockade and monitor blood pressure and heart rate closely. Adjust doses to avoid orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Nadolol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine causes alpha-blockade and vasodilation, and adding nadolol can increase hypotension. In pheochromocytoma, beta-blockers are used after alpha-blockade is established to avoid unopposed alpha stimulation and hypertensive crisis.
How serious is the interaction between Nadolol and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the beta-blocker only after adequate alpha-blockade and monitor blood pressure and heart rate closely. Adjust doses to avoid orthostatic hypotension.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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