Drug interactions
Nadolol + Pirbuterol
Severity: Major
Nadolol and Pirbuterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a nonselective beta-blocker that directly opposes the bronchodilating action of pirbuterol. This can reduce relief of bronchospasm and may precipitate severe bronchoconstriction in patients with asthma or COPD.
What this interaction means in plain words
Nadolol and Pirbuterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Avoid nonselective beta-blockers in patients who need beta-agonist bronchodilators; use an alternative antihypertensive or antianginal class. If unavoidable, monitor respiratory function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Pirbuterol?
MediHelp rates the interaction as major. Nadolol and Pirbuterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a nonselective beta-blocker that directly opposes the bronchodilating action of pirbuterol. This can reduce relief of bronchospasm and may precipitate severe bronchoconstriction in patients with asthma or COPD.
How serious is the interaction between Nadolol and Pirbuterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients who need beta-agonist bronchodilators; use an alternative antihypertensive or antianginal class. If unavoidable, monitor respiratory function closely.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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