Drug interactions
Nadolol + Rivastigmine
Severity: Moderate
Nadolol and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine increases cholinergic tone and can cause bradycardia and syncope, and nadolol is a nonselective beta-blocker that slows heart rate and AV conduction. Combined use raises the risk of marked bradycardia, heart block and falls, especially in older patients.
What this interaction means in plain words
Nadolol and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Rivastigmine belongs to Central Nervous System.
Why it happens
Additive bradycardic effects from vagotonic cholinesterase inhibition and beta-blockade.
What to do
Monitor pulse and blood pressure when starting or titrating either drug and ask about dizziness or falls. Reduce the dose or change therapy if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivastigmine
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Rivastigmine?
MediHelp rates the interaction as moderate. Nadolol and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine increases cholinergic tone and can cause bradycardia and syncope, and nadolol is a nonselective beta-blocker that slows heart rate and AV conduction. Combined use raises the risk of marked bradycardia, heart block and falls, especially in older patients.
How serious is the interaction between Nadolol and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and blood pressure when starting or titrating either drug and ask about dizziness or falls. Reduce the dose or change therapy if symptomatic bradycardia occurs.
What other medicines interact with Rivastigmine?
MediHelp also lists interactions of Rivastigmine with, for example, Donepezil, Galantamine, Memantine-donepezil. The full list is on the Rivastigmine page.
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