Drug interactions
Nadolol + Sacubitril / valsartan
Severity: Moderate
Nadolol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and combination is used in heart failure, but the additive effect may cause hypotension, dizziness or renal function change. Sacubitril/valsartan can raise potassium, and is contraindicated in pregnancy because of fetal toxicity.
What this interaction means in plain words
Nadolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive pharmacodynamic effects; the angiotensin receptor blocker component may raise potassium.
What to do
Monitor blood pressure, renal function and potassium after initiation and dose changes. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Nadolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and combination is used in heart failure, but the additive effect may cause hypotension, dizziness or renal function change. Sacubitril/valsartan can raise potassium, and is contraindicated in pregnancy because of fetal toxicity.
How serious is the interaction between Nadolol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium after initiation and dose changes. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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