Drug interactions
Nadolol + Salsalate
Severity: Minor
Nadolol and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a non-acetylated salicylate, has weak effect on prostaglandins but may at high doses reduce the antihypertensive effect of beta-blockers. Renal and fluid retention effects are less than with other NSAIDs.
What this interaction means in plain words
Nadolol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild inhibition of prostaglandin synthesis may cause sodium and water retention opposing the effect of nadolol.
What to do
Monitor blood pressure if salsalate is used long term at high doses. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Salsalate?
MediHelp rates the interaction as minor. Nadolol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate, a non-acetylated salicylate, has weak effect on prostaglandins but may at high doses reduce the antihypertensive effect of beta-blockers. Renal and fluid retention effects are less than with other NSAIDs.
How serious is the interaction between Nadolol and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if salsalate is used long term at high doses. No routine dose change is needed.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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