Drug interactions
Nadolol + Saquinavir
Severity: Moderate
Nadolol and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir can prolong PR and QT intervals, and nadolol slows AV conduction, so the combination may increase the risk of bradycardia, AV block and arrhythmia. This is of greater concern in patients with conduction disease or structural heart disease.
What this interaction means in plain words
Nadolol and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac conduction (AV nodal slowing from beta-blockade plus saquinavir-related PR/QT prolongation).
What to do
Obtain a baseline ECG and monitor heart rate and PR interval. Choose an alternative antiretroviral or antihypertensive in patients with conduction abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Saquinavir?
MediHelp rates the interaction as moderate. Nadolol and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir can prolong PR and QT intervals, and nadolol slows AV conduction, so the combination may increase the risk of bradycardia, AV block and arrhythmia. This is of greater concern in patients with conduction disease or structural heart disease.
How serious is the interaction between Nadolol and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and PR interval. Choose an alternative antiretroviral or antihypertensive in patients with conduction abnormalities.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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