Drug interactions
Nadolol + Telmisartan-amlodipine
Severity: Moderate
Nadolol and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol adds to the blood pressure lowering of the combination and may cause bradycardia, hypotension or fatigue. Nadolol is renally cleared, and dehydration or reduced kidney function from the diuretic and ARB can increase its exposure. Beta-blockers can also mask hypoglycemia symptoms in diabetic patients.
What this interaction means in plain words
Nadolol and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of non-selective beta-blockade, angiotensin receptor blockade and calcium channel blockade.
What to do
Monitor heart rate, blood pressure and renal function when starting or adjusting doses, and reduce doses if symptomatic hypotension or bradycardia occurs. Avoid use in pregnancy because of the ARB component.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Nadolol and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol adds to the blood pressure lowering of the combination and may cause bradycardia, hypotension or fatigue. Nadolol is renally cleared, and dehydration or reduced kidney function from the diuretic and ARB can increase its exposure. Beta-blockers can also mask hypoglycemia symptoms in diabetic patients.
How serious is the interaction between Nadolol and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and renal function when starting or adjusting doses, and reduce doses if symptomatic hypotension or bradycardia occurs. Avoid use in pregnancy because of the ARB component.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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