Drug interactions
Nadolol + Terbutaline
Severity: Major
Nadolol and Terbutaline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that blocks beta-2 receptors, directly opposing terbutaline's bronchodilation and potentially causing severe bronchospasm in patients with asthma or COPD. Terbutaline's therapeutic effect may be markedly reduced.
What this interaction means in plain words
Nadolol and Terbutaline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nadolol belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism through non-selective beta-adrenergic receptor blockade.
What to do
Avoid non-selective beta-blockers in patients who need terbutaline; use an alternative antihypertensive or antianginal class. If unavoidable, monitor respiratory function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Terbutaline
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Terbutaline?
MediHelp rates the interaction as major. Nadolol and Terbutaline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that blocks beta-2 receptors, directly opposing terbutaline's bronchodilation and potentially causing severe bronchospasm in patients with asthma or COPD. Terbutaline's therapeutic effect may be markedly reduced.
How serious is the interaction between Nadolol and Terbutaline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients who need terbutaline; use an alternative antihypertensive or antianginal class. If unavoidable, monitor respiratory function closely.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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