Drug interactions
Nadolol + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Nadolol and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and can oppose the bronchodilation produced by vilanterol. In patients with COPD or asthma this may cause bronchospasm and loss of control of airflow obstruction.
What this interaction means in plain words
Nadolol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors between a non-selective beta-blocker and a long-acting beta-2 agonist.
What to do
Avoid nadolol in patients with COPD who need vilanterol; if a beta-blocker is essential, choose a cardioselective beta-1 agent such as bisoprolol or metoprolol at the lowest effective dose. Monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Nadolol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and can oppose the bronchodilation produced by vilanterol. In patients with COPD or asthma this may cause bronchospasm and loss of control of airflow obstruction.
How serious is the interaction between Nadolol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nadolol in patients with COPD who need vilanterol; if a beta-blocker is essential, choose a cardioselective beta-1 agent such as bisoprolol or metoprolol at the lowest effective dose. Monitor respiratory symptoms and lung function.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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