Drug interactions
Nadolol + Vilanterol / fluticasone furoate inhaled
Severity: Major
Nadolol and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and can oppose the bronchodilating effect of vilanterol. This may precipitate bronchospasm and worsen asthma or COPD control.
What this interaction means in plain words
Nadolol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors between a non-selective beta-blocker and a long-acting beta-2 agonist.
What to do
Avoid nadolol in patients with reactive airway disease receiving vilanterol; if a beta-blocker is necessary, use a cardioselective beta-1 agent at the lowest effective dose. Monitor respiratory status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Nadolol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and can oppose the bronchodilating effect of vilanterol. This may precipitate bronchospasm and worsen asthma or COPD control.
How serious is the interaction between Nadolol and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nadolol in patients with reactive airway disease receiving vilanterol; if a beta-blocker is necessary, use a cardioselective beta-1 agent at the lowest effective dose. Monitor respiratory status closely.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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