Drug interactions
Nadolol + Yohimbe
Severity: Moderate
Nadolol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 adrenergic antagonist that raises sympathetic outflow, blood pressure and heart rate. Nadolol, a nonselective beta-blocker, may blunt the tachycardia but leaves alpha-mediated vasoconstriction unopposed, so the antihypertensive effect of nadolol may be reduced.
What this interaction means in plain words
Nadolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: yohimbine increases noradrenergic activity through alpha-2 blockade, opposing the blood pressure lowering of beta-blockade.
What to do
Advise patients to avoid yohimbe products while on nadolol. If used, monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Yohimbe?
MediHelp rates the interaction as moderate. Nadolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe contains yohimbine, an alpha-2 adrenergic antagonist that raises sympathetic outflow, blood pressure and heart rate. Nadolol, a nonselective beta-blocker, may blunt the tachycardia but leaves alpha-mediated vasoconstriction unopposed, so the antihypertensive effect of nadolol may be reduced.
How serious is the interaction between Nadolol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products while on nadolol. If used, monitor blood pressure and heart rate.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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