Drug interactions
Nafcillin + Nicardipine
Severity: Moderate
Nafcillin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and can reduce the concentrations of CYP3A4-metabolized drugs such as nicardipine. This may lead to reduced antihypertensive or antianginal effect during therapy, and levels may rebound after nafcillin is stopped.
What this interaction means in plain words
Nafcillin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing hepatic and intestinal metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate during nafcillin therapy and increase the nicardipine dose if control is lost. Reduce the dose again after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nafcillin with Nicardipine?
MediHelp rates the interaction as moderate. Nafcillin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and can reduce the concentrations of CYP3A4-metabolized drugs such as nicardipine. This may lead to reduced antihypertensive or antianginal effect during therapy, and levels may rebound after nafcillin is stopped.
How serious is the interaction between Nafcillin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during nafcillin therapy and increase the nicardipine dose if control is lost. Reduce the dose again after nafcillin is stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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