Drug interactions
Nafcillin + Nimodipine
Severity: Moderate
Nafcillin and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and can lower concentrations of CYP3A4 substrates. Nimodipine levels may fall, reducing its effect during a course of nafcillin.
What this interaction means in plain words
Nafcillin and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing nimodipine metabolism.
What to do
Monitor clinical response and blood pressure during and after nafcillin therapy. Adjust the nimodipine dose if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nafcillin with Nimodipine?
MediHelp rates the interaction as moderate. Nafcillin and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and can lower concentrations of CYP3A4 substrates. Nimodipine levels may fall, reducing its effect during a course of nafcillin.
How serious is the interaction between Nafcillin and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood pressure during and after nafcillin therapy. Adjust the nimodipine dose if efficacy is lost.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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