Drug interactions
Nafcillin + Paclitaxel
Severity: Moderate
Nafcillin and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of CYP3A4 and can reduce exposure to CYP3A4 substrates. Paclitaxel levels might fall, potentially reducing efficacy, though no clinical data confirm this.
What this interaction means in plain words
Nafcillin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4 (and possibly CYP2C8), increasing paclitaxel metabolism.
What to do
Where possible choose a non-inducing antibiotic; otherwise monitor for reduced paclitaxel response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Nafcillin with Paclitaxel?
MediHelp rates the interaction as moderate. Nafcillin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is an inducer of CYP3A4 and can reduce exposure to CYP3A4 substrates. Paclitaxel levels might fall, potentially reducing efficacy, though no clinical data confirm this.
How serious is the interaction between Nafcillin and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose a non-inducing antibiotic; otherwise monitor for reduced paclitaxel response.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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