Drug interactions
Nafcillin + Probenecid
Severity: Minor
Nafcillin and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal tubular secretion of penicillins and raises their plasma levels. Nafcillin is mainly cleared by the liver, so the effect is likely smaller and generally tolerable.
What this interaction means in plain words
Nafcillin and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probenecid inhibits renal tubular secretion of penicillins via organic anion transporters.
What to do
No routine adjustment is needed; be aware that nafcillin levels may rise. Monitor for adverse effects with high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Nafcillin with Probenecid?
MediHelp rates the interaction as minor. Nafcillin and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid reduces renal tubular secretion of penicillins and raises their plasma levels. Nafcillin is mainly cleared by the liver, so the effect is likely smaller and generally tolerable.
How serious is the interaction between Nafcillin and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware that nafcillin levels may rise. Monitor for adverse effects with high doses.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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