Drug interactions
Nafcillin + Quetiapine
Severity: Moderate
Nafcillin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may lower quetiapine exposure, which could lead to loss of antipsychotic effect. The effect is expected to be modest and is mainly relevant during prolonged nafcillin courses. Evidence is largely from CYP3A4 induction reported with nafcillin.
What this interaction means in plain words
Nafcillin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing the metabolism of quetiapine.
What to do
Monitor for worsening psychiatric symptoms during nafcillin therapy and consider a quetiapine dose increase if response falls. Reassess the quetiapine dose after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Nafcillin with Quetiapine?
MediHelp rates the interaction as moderate. Nafcillin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin may lower quetiapine exposure, which could lead to loss of antipsychotic effect. The effect is expected to be modest and is mainly relevant during prolonged nafcillin courses. Evidence is largely from CYP3A4 induction reported with nafcillin.
How serious is the interaction between Nafcillin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening psychiatric symptoms during nafcillin therapy and consider a quetiapine dose increase if response falls. Reassess the quetiapine dose after nafcillin is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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