Drug interactions
Nafcillin + Regorafenib
Severity: Moderate
Nafcillin and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower regorafenib exposure, risking reduced efficacy.
What this interaction means in plain words
Nafcillin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing regorafenib clearance.
What to do
Use an alternative antibiotic that does not induce CYP3A4 if possible, or monitor for reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Nafcillin with Regorafenib?
MediHelp rates the interaction as moderate. Nafcillin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower regorafenib exposure, risking reduced efficacy.
How serious is the interaction between Nafcillin and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic that does not induce CYP3A4 if possible, or monitor for reduced response.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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