Drug interactions
Nafcillin + Repaglinide
Severity: Moderate
Nafcillin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower repaglinide exposure, reducing its glucose-lowering effect. The effect is most relevant during prolonged therapy.
What this interaction means in plain words
Nafcillin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4 and increases repaglinide metabolism.
What to do
Monitor blood glucose during nafcillin therapy and increase repaglinide if hyperglycemia develops. Re-check glucose after nafcillin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Nafcillin with Repaglinide?
MediHelp rates the interaction as moderate. Nafcillin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and may lower repaglinide exposure, reducing its glucose-lowering effect. The effect is most relevant during prolonged therapy.
How serious is the interaction between Nafcillin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during nafcillin therapy and increase repaglinide if hyperglycemia develops. Re-check glucose after nafcillin is discontinued.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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