Drug interactions
Nafcillin + Roflumilast
Severity: Moderate
Nafcillin and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer that may lower roflumilast exposure. The effect is usually temporary because nafcillin is used for short courses.
What this interaction means in plain words
Nafcillin and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing roflumilast metabolism.
What to do
Monitor for loss of respiratory symptom control during the antibiotic course. Expect induction to wane over weeks after stopping nafcillin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Frequently asked questions
Can I take Nafcillin with Roflumilast?
MediHelp rates the interaction as moderate. Nafcillin and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer that may lower roflumilast exposure. The effect is usually temporary because nafcillin is used for short courses.
How serious is the interaction between Nafcillin and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of respiratory symptom control during the antibiotic course. Expect induction to wane over weeks after stopping nafcillin.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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