Drug interactions
Nafcillin + Tamsulosin
Severity: Minor
Nafcillin and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower tamsulosin exposure. Reduced efficacy is possible during prolonged courses.
What this interaction means in plain words
Nafcillin and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin induces CYP3A4, increasing tamsulosin metabolism.
What to do
Monitor urinary symptom control during prolonged nafcillin therapy. Titrate tamsulosin if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Nafcillin with Tamsulosin?
MediHelp rates the interaction as minor. Nafcillin and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4 and may lower tamsulosin exposure. Reduced efficacy is possible during prolonged courses.
How serious is the interaction between Nafcillin and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control during prolonged nafcillin therapy. Titrate tamsulosin if response is reduced.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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