Drug interactions
Nafcillin + Terbinafine
Severity: Minor
Nafcillin and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may lower terbinafine concentrations. The effect is likely modest and limited to the period of nafcillin therapy.
What this interaction means in plain words
Nafcillin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin induces CYP3A4, increasing terbinafine metabolism.
What to do
Monitor antifungal response if both are used for a prolonged period. No upfront dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Nafcillin with Terbinafine?
MediHelp rates the interaction as minor. Nafcillin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin can induce CYP3A4 and may lower terbinafine concentrations. The effect is likely modest and limited to the period of nafcillin therapy.
How serious is the interaction between Nafcillin and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antifungal response if both are used for a prolonged period. No upfront dose change is needed.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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