Drug interactions
Nafcillin + Ticagrelor
Severity: Moderate
Nafcillin and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower ticagrelor and its active metabolite exposure. This could reduce platelet inhibition and weaken protection against stent thrombosis or recurrent ischemic events.
What this interaction means in plain words
Nafcillin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of intestinal and hepatic CYP3A4 by nafcillin increases ticagrelor metabolism.
What to do
Where possible choose a non-inducing antibiotic, or limit the duration of nafcillin therapy. If combined, watch for ischemic events and consider whether an alternative antiplatelet is appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Nafcillin with Ticagrelor?
MediHelp rates the interaction as moderate. Nafcillin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower ticagrelor and its active metabolite exposure. This could reduce platelet inhibition and weaken protection against stent thrombosis or recurrent ischemic events.
How serious is the interaction between Nafcillin and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose a non-inducing antibiotic, or limit the duration of nafcillin therapy. If combined, watch for ischemic events and consider whether an alternative antiplatelet is appropriate.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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