Drug interactions
Nafcillin + Verapamil
Severity: Moderate
Nafcillin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can reduce verapamil exposure, which may cause loss of blood pressure or heart rate control. Reports of reduced calcium channel blocker effect with nafcillin support clinical relevance.
What this interaction means in plain words
Nafcillin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing the metabolism of verapamil.
What to do
Monitor blood pressure and heart rate during and after nafcillin therapy, and increase the verapamil dose if effect is lost. Reduce it again after nafcillin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nafcillin with Verapamil?
MediHelp rates the interaction as moderate. Nafcillin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can reduce verapamil exposure, which may cause loss of blood pressure or heart rate control. Reports of reduced calcium channel blocker effect with nafcillin support clinical relevance.
How serious is the interaction between Nafcillin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during and after nafcillin therapy, and increase the verapamil dose if effect is lost. Reduce it again after nafcillin is discontinued.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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