Drug interactions
Nafcillin + Vinblastine
Severity: Moderate
Nafcillin and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower vinblastine concentrations. Reduced exposure could diminish antitumor efficacy, although clinical data are sparse.
What this interaction means in plain words
Nafcillin and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing vinblastine metabolism.
What to do
Use an alternative antibiotic that does not induce CYP3A4 when feasible. If not possible, monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Nafcillin with Vinblastine?
MediHelp rates the interaction as moderate. Nafcillin and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower vinblastine concentrations. Reduced exposure could diminish antitumor efficacy, although clinical data are sparse.
How serious is the interaction between Nafcillin and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic that does not induce CYP3A4 when feasible. If not possible, monitor treatment response.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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