Drug interactions
Nafcillin + Ziprasidone
Severity: Minor
Nafcillin and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower concentrations of drugs metabolized by this enzyme. Because CYP3A4 is a secondary route for ziprasidone, the reduction is likely small, though therapeutic effect could weaken during prolonged courses.
What this interaction means in plain words
Nafcillin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increasing ziprasidone clearance.
What to do
Monitor psychiatric response during prolonged nafcillin therapy. Adjust the ziprasidone dose if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Nafcillin with Ziprasidone?
MediHelp rates the interaction as minor. Nafcillin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4 and may lower concentrations of drugs metabolized by this enzyme. Because CYP3A4 is a secondary route for ziprasidone, the reduction is likely small, though therapeutic effect could weaken during prolonged courses.
How serious is the interaction between Nafcillin and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response during prolonged nafcillin therapy. Adjust the ziprasidone dose if symptoms worsen.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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